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Dr. Paulo de Valdoleiros
MBChB (University of the Free State) is a General practitioner with a sole interest in functional and anti-aging medicine and who specializes in: Modalities: Anti-aging medicine, Chelation, Functional medicine, Intravenous therapy, Lifestyle modification, Mindfulness-based Interventions, Nutrition, Western Medicine.
Date: November 19 | Time: 07:00PM
BERBERINE – REVERSING METABOLIC DYSFUNCTION
The metabolic syndrome is a cluster of multiple metabolic diseases based on obesity and insulin resistance. Obesity leads to insulin resistance and a proatherogenic state. Therefore, the role of obesity, especially visceral (or central or abdominal) obesity, is believed to be the main physiological force resulting in disorders of glucose and lipid metabolism in metabolic syndrome.
Berberine is an isoquinoline derivative alkaloid isolated from many kinds of medicinal herbs, such as Hydrastis canadensis (goldenseal), Cortex Phellodendri (Huangbai), and Rhizoma Coptidis (Huanglian). It is safe and cheap and has been extensively used as an antibacterial drug. Berberine has been proven to have many other pharmacological effects including antimicrobial, antitumor, anti-inflammation, blood glucose lowering, and even inhibiting chronic cocaine-induced sensitization. In a recent single-blind clinical observation, the study showed that diet supplementation of some natural substances including berberine was beneficial for correcting lipid metabolism disorders and reducing cardiovascular risk factors. Large sample, well-designed clinical studies, indicate that berberine improves glucose and lipid metabolism disorders. More particularly, studies have shown that berberine can improve insulin sensitivity by adjusting adipokine secretion both in primarily cultured preadipocytes as well as in metabolic syndrome patients,
In this session, Dr de Valdoleiros will explore well-designed clinical studies, indicating that berberine improves glucose and lipid metabolism disorders and how berberine can improve insulin sensitivity by adjusting adipokine secretion in metabolic syndrome patients
- DM2 lifestyle and biochemical bases revisited
- Reversibility of DM2 – challenges and victories
- Berberine – a plant alkaloid with history and tradition
- Berberine and cellular energy homeostasis
- AMP-activated protein kinase (AMPK) signalling pathway: regulation and downstream effects
- Specific practical application of Berberine’s benefits to DM2